Minute™ Total Protein Extraction Kit for Animal Cultured Cells and Tissues (50 Preps)

Manual & Protocol | Material Safety Data Sheets (MSDS)

Minute^TM total protein extraction kit for animal cultured cells and tissues is the most advanced next-generation tool for super-fast protein extraction without altered protein profile usually associated with solution-based procedures. More and more evidence has shown that the most commonly used RIPA buffer can cause unpredictable protein loss, resulting in questionable data interpretation. This problem is fully resolved using the patented spin column-based technologies. Coupled with stronger lysis buffers, the spin column makes protein extraction super easy and efficient. The extraction volume can be as low as 20 µl – a helpful feature when starting material is a limiting factor. This kit provides denaturing and native cell lysis buffers so users can select according to specific applications. Total proteins can be extracted from cultured cells/tissues in 1-8 min with high yield (2-8 mg/ml).

-RIPA Buffer - The Potential Troubles

-Pitfalls of Protein Extraction by RIPA

-A Technical Breakthrough for Protein Sample Preparation

Selected references related to protein loss by RIPA buffer:

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3. Li, Q. (2016) Biotechniques. 61:327
4. Ngoka, L. CM. (2008) Proteome Science. 6:30

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94.  Wang, L. J., Xiao, Y., Fang, J., Wang, J. L., Zhang, H., Meng, X. X., ... & Gu, R. (2020). PGF2α stimulates 10-pS Cl channel and thiazide-sensitive Na-Cl cotransporter (NCC) in distal convoluted tubule. American Journal of Physiology-Renal Physiology.

95.  Chen, H., Xiao, H., Gan, H., Zhang, L., Wang, L., Li, S., ... & Zhao, J. (2020). HIF-2α promotes angiogenesis via VEGF/Notch1 pathway and exerts neuroprotective effects after intracerebral haemorrhage injury. Neuroscience.

96. Guo, W., Zhang, F., Yang, S., Rao, B., Wang, Y., Li, X., & Li, S. (2020). Two Coordination Polymers Containing 4, 4′-Di (1H-Benzo [D] Imidazol-1-yl) Biphenyl Ligand: Crystal Structures and Anticancer Activity on Human Multiple Myeloma Cells. Journal of Structural Chemistry, 61(5), 780-788.
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100. Shimizu, Y., Tamura, T., Kemmochi, A., Owada, Y., Ozawa, Y., Katsuji, H., ... & Oda, T. Oxidative stress and LXR agonist induce hepatocellular carcinoma in NASH model. Journal of Gastroenterology and Hepatology.

101. Ye, C. H., Chen, G., & Gong, Y. L. (2020). Two Heteroligand Cd (II)-coordination Polymers: Crystal Structures and Anti-Lung Cancer Activity Evaluation. Russian Journal of Coordination Chemistry, 46(9), 653-661.

102. Liu, C., Zhang, N., Zhang, R., Jin, L., Petridis, A. K., Loers, G., ... & Siebert, H. C. (2020). Cuprizone-induced demyelination in mouse hippocampus is alleviated by ketogenic diet. Journal of Agricultural and Food Chemistry.

103. Zhang, N., Liu, C., Jin, L., Zhang, R., Wang, T., Wang, Q., ... & Zheng, X. (2020). Ketogenic Diet Elicits Antitumor Properties through Inducing Oxidative Stress, Inhibiting MMP-9 Expression, and Rebalancing M1/M2 Tumor-Associated Macrophage Phenotype in a Mouse Model of Colon Cancer. Journal of Agricultural and Food Chemistry.\

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210. Han, P., Wang, F., Bao, S., Yao, G., Wan, X., Liu, J., & Jiang, H. (2023). Design and synthesis of a clickable, photoreactive amino acid p-(4-(but-3-yn-1-yl) benzoyl)-L-phenylalanine for peptide photoaffinity labeling. RSC Advances, 13(2), 866-872.

211. Wang, Z., Gao, C., Zhang, L., & Sui, R. (2023). Hesperidin methylchalcone (HMC) hinders amyloid-β induced Alzheimer's disease by attenuating cholinesterase activity, macromolecular damages, oxidative stress and apoptosis via regulating NF-κB and Nrf2/HO-1 pathways. International Journal of Biological Macromolecules, 123169.
212. Sun, W., Ma, J., Chen, M., Zhang, W., Xu, C., Nan, Y., ... & Wang, Y. (2023). 4-Iodo-6-phenylpyrimidine (4-IPP) suppresses fibroblast-like synoviocyte-mediated inflammation and joint destruction associated with rheumatoid arthritis. International Immunopharmacology, 115, 109714.

213. Wang, L., Li, S., Cai, K., Xiao, Y., & Ye, L. (2023). TLR7 agonists modulate the activation of human conjunctival epithelial cells induced by IL-1β via the ERK1/2 signaling pathway.

214. Yamaki, H., Kono, M., Wakisaka, R., Komatsuda, H., Kumai, T., Hayashi, R., ... & Katada, A. (2023). Brachyury-targeted immunotherapy combined with gemcitabine against head and neck cancer.

215. Li, K., Kratzmann, V., Dai, M., Gatzke, N., Rocic, P., Bramlage, P., ... & Hillmeister, P. (2023). Angiotensin receptor-neprilysin inhibitor improves coronary collateral perfusion. Frontiers in Cardiovascular Medicine, 9, 981333.

216. Murakami, T., Ito, Y., Sango, K., Watabe, K., & Sunada, Y. (2023). Human transthyretin gene expression is markedly increased in repair Schwann cells in an in vitro model of hereditary transthyretin amyloidosis. Neurochemistry International, 105507.
217. Li, S., Zheng, Y., Long, Q., Nong, J., Shao, H., Liang, G., & Wu, F. (2023). Drug-drug interactions between propofol and ART drugs: inhibiting neuronal activity by affecting glucose metabolism.

218. Komatsuda, H., Wakisaka, R., Kono, M., Kumai, T., Hayashi, R., Yamaki, H., ... & Kobayashi, H. (2023). Mitogen-activated protein kinase inhibition augments the T cell response against HOXB7-expressing tumor through human leukocyte antigen upregulation. Cancer Science, 114(2), 399-409.

219. Huang, C., Zhao, S., Yang, Y., Guo, T., Ke, H., Mi, X., ... & Zhao, S. (2023). TP63 gain-of-function mutations cause premature ovarian insufficiency by inducing oocyte apoptosis. Journal of Clinical Investigation, 133(5), e162315.

220. Liu, Y., Xiao, X., Wang, J., Wang, Y., & Yu, Y. (2023). Silencing CircEIF3I/miR-526b-5p Axis Epigenetically Targets HGF/c-Met Signal to Hinder the Malignant Growth, Metastasis and Angiogenesis of Hepatocellular Carcinoma. Biochemical Genetics, 61(1), 48-68.

221. Tingyang Zhou, Wenjing Liao, Xiaofen Wang, Yiyan Wang, Pingchang Yang, Li Zuo, Xiaowen Zhang,Low temperature reduces occludin expression in bronchial epithelial cells: Implications in cold-induced asthma,Molecular Immunology,
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222. Li E, Yan K, Zhang R, et al. Kaempferol Protects Against Apoptosis  in PC12 Cells Exposed to Hydrogen Peroxide by Activating Akt1. Natural Product Communications. 2023;18(4). doi:10.1177/1934578X231170448

223. F Chen, C Chu, X Wang, C Yang, Y Deng, Z Duan.(2023).Hesperetin attenuates sepsis-induced intestinal barrier injury by regulating neutrophil extracellular trap formation via the ROS/autophagy signaling pathway.Food&Function.

224. Liu, P., Zhou, J., Xu, J., Ruan, G., Ding, C., & Wang, K. Vitamin D Plays a Protective Role in Osteoarthritis by Inhibiting the Nuclear Transcription Factor-κB (NF-κB)-Regulated Adenosine Monophosphate Activated Protein Kinase (AMPK)/Mammalian Target of Rapamycin (mTOR) Signaling Pathway to Activate Chondrocyte Autophagy.

225. Zhang, H., Xie, L., Zhang, N., Qi, X., Lu, T., Xing, J., ... & Liu, G. (2023). Donkey Oil-Based Ketogenic Diet Prevents Tumor Progression by Regulating Intratumor Inflammation, Metastasis and Angiogenesis in CT26 Tumor-Bearing Mice. Genes, 14(5), 1024.

226.  Guan, L., Yang, Y., Lu, Y., Chen, Y., Luo, X., Xin, D., ... & Wang, F. (2023). Reactivation of mutant p53 in esophageal squamous cell carcinoma by isothiocyanate inhibits tumor growth. Frontiers in Pharmacology, 14, 1089.

227. Wang, B. et al. (2023). Oxidative stress initiates RIPK3/MLKL-mediated corneal epithelial necroptosis and NLRP3 inflammasome signaling during fungal keratitis. The American Journal of Pathology. 
228. Wang, Y., Zhang, L., Zhang, L., Li, J., Sheng, Z., Du, Y., ... & Yu, X. (2023). Intervention with extracellular matrix metalloproteinase inducer in osteoclasts attenuates periodontitis-induced bone resorption. Odontology, 1-10.

229. Huang, H., Kuang, X., Zou, Y., Zeng, J., Du, H., Tang, H., ... & Shen, H. (2023). MAP4K4 is involved in the neuronal development of retinal photoreceptors. Experimental Eye Research, 109524.

230. Li, K., Kratzmann, V., Dai, M., Gatzke, N., Rocic, P., Bramlage, P., ... & Hillmeister, P. (2023). Angiotensin receptor-neprilysin inhibitor improves coronary collateral perfusion. Frontiers in Cardiovascular Medicine, 9, 981333.

231. Buerer, L., Clark, N., Welch, A., Duan, C., Taggart, A., Townley, B., ... & Fairbrother, W. (2023). The debranching enzyme Dbr1 regulates lariat turnover and intron splicing.

232. Wang, S., Cai, Q., Xu, L., Sun, Y., Wang, M., Wang, Y., ... & Ni, Z. (2023). Isoalantolactone relieves depression-like behaviors in mice after chronic social defeat stress via the gut-brain axis. Psychopharmacology, 1-13.

233. Liu, Y., Han, Y., Zhu, W., Luo, Q., Yuan, J., & Liu, X. (2023). Characterization of N-glycome profile in mouse brain tissue regions by MALDI-TOF/MS. Analytical and Bioanalytical Chemistry, 1-14.

234. Clark, N. E., Katolik, A., Gallant, P., Welch, A., Murphy, E., Buerer, L., ... & Fairbrother, W. G. (2023). Activation of human RNA lariat debranching enzyme Dbr1 by binding protein TTDN1 occurs though an intrinsically disordered C-terminal domain. Journal of Biological Chemistry, 105100.

235. Lin, J. J., Luo, B. H., Su, T., Yang, Q., Zhang, Q. F., Dai, W. Y., ... & Xiang, L. (2023). Antitumor activity of miR-188-3p in gastric cancer is achieved by targeting CBL expression and inactivating the AKT/mTOR signaling. World Journal of Gastrointestinal Oncology, 15(8), 1384-1399.

236. Li, S., Wang, L., Wang, J., Liang, B., Gao, W., Huang, Y., ... & Wang, Z. (2023). Inhibition of AGEs-RAGE-PP2A axis alleviates cognitive impairment after chronic heart failure. Cellular and Molecular Biology, 69(5), 179-185.

237. Liu, Z., Cui, L., Li, X., Xu, L., Zhang, Y., Han, Z., ... & Li, H. (2023). Characterization of the Effects of Host p53 and Fos on Gallid Alpha Herpesvirus 1 Replication. Genes, 14(8), 1615.
238. Luo, D., Chen, M., Li, Q., Wang, K., Wang, K., Li, J., ... & Li, X. (2023). CUL4B-DDB1-COP1-mediated UTX downregulation promotes colorectal cancer progression. Experimental Hematology & Oncology, 12(1), 77.
     

239. Hou, J., Yun, Y., Jeon, B., Baek, J., & Kim, S. (2023). Ginsenoside F1-Mediated Telomere Preservation Delays Cellular Senescence. International Journal of Molecular Sciences, 24(18), 14241.

240. Chu, C., Wang, X., Chen, F., Yang, C., Shi, L., Xu, W., ... & Ding, W. (2023). Neutrophil extracellular traps aggravate intestinal epithelial necroptosis in ischaemia–reperfusion by regulating TLR4/RIPK3/FUNDC1‐required mitophagy. Cell Proliferation, e13538.