Minute™ Total Protein Extraction Kit for Animal Cultured Cells and Tissues (50 Preps)

Manual & Protocol | Material Safety Data Sheets (MSDS)

Minute^TM total protein extraction kit for animal cultured cells and tissues is the most advanced next-generation tool for super-fast protein extraction without altered protein profile usually associated with solution-based procedures. More and more evidence has shown that the most commonly used RIPA buffer can cause unpredictable protein loss, resulting in questionable data interpretation. This problem is fully resolved using the patented spin column-based technologies. Coupled with stronger lysis buffers, the spin column makes protein extraction super easy and efficient. The extraction volume can be as low as 20 µl – a helpful feature when starting material is a limiting factor. This kit provides denaturing and native cell lysis buffers so users can select according to specific applications. Total proteins can be extracted from cultured cells/tissues in 1-8 min with high yield (2-8 mg/ml).

-RIPA Buffer - The Potential Troubles

-Pitfalls of Protein Extraction by RIPA

-A Technical Breakthrough for Protein Sample Preparation

Selected references related to protein loss by RIPA buffer:

1. Bai, B., and Laiho, M. (2012) Proteomics. 12:3044-3048
2. Mukhopadhyay, C. et al. (2016) PNAS 5:8228-8237
3. Li, Q. (2016) Biotechniques. 61:327
4. Ngoka, L. CM. (2008) Proteome Science. 6:30

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   206. Zhang, L., Guo, Y. N., Liu, J., Wang, L. H., Wu, H. Q., Wang, T., ... & Ye, X. H. (2022). Plantamajoside attenuates cardiac fibrosis via inhibiting AGEs activated‐RAGE/autophagy/EndMT pathway. Phytotherapy Research.

   207. Wang, S., Zhang, J., Wang, K., Zhao, Y., & Liu, D. (2022). ADAMTS1 as potential prognostic biomarker promotes malignant invasion of glioma. International Journal of Clinical Oncology, 1-17.

   208. Xiong, Y., Jiang, C., Amir, M. B., Dong, Y., Xie, L., Liao, Y., ... & Chen, W. (2022). Antibody-Based Methods Reveal the Protein Expression Properties of Glucosinolate Sulfatase 1 and 2 in Plutella xylostella. Journal of Insect Science, 22(6), 5.

   209.  Wang, B., Zeng, H., Zuo, X., Yang, X., Wang, X., He, D., & Yuan, J. (2022). TLR4-dependent DUOX2 activation triggered oxidative stress and promoted HMGB1 release in dry eye. Frontiers in medicine, 8, 2814.

   210. Han, P., Wang, F., Bao, S., Yao, G., Wan, X., Liu, J., & Jiang, H. (2023). Design and synthesis of a clickable, photoreactive amino acid p-(4-(but-3-yn-1-yl) benzoyl)-L-phenylalanine for peptide photoaffinity labeling. RSC Advances, 13(2), 866-872.

   211. Wang, Z., Gao, C., Zhang, L., & Sui, R. (2023). Hesperidin methylchalcone (HMC) hinders amyloid-β induced Alzheimer's disease by attenuating cholinesterase activity, macromolecular damages, oxidative stress and apoptosis via regulating NF-κB and Nrf2/HO-1 pathways. International Journal of Biological Macromolecules, 123169.
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   213. Wang, L., Li, S., Cai, K., Xiao, Y., & Ye, L. (2023). TLR7 agonists modulate the activation of human conjunctival epithelial cells induced by IL-1β via the ERK1/2 signaling pathway.

   214. Yamaki, H., Kono, M., Wakisaka, R., Komatsuda, H., Kumai, T., Hayashi, R., ... & Katada, A. (2023). Brachyury-targeted immunotherapy combined with gemcitabine against head and neck cancer.

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   218. Komatsuda, H., Wakisaka, R., Kono, M., Kumai, T., Hayashi, R., Yamaki, H., ... & Kobayashi, H. (2023). Mitogen-activated protein kinase inhibition augments the T cell response against HOXB7-expressing tumor through human leukocyte antigen upregulation. Cancer Science, 114(2), 399-409.

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   220. Liu, Y., Xiao, X., Wang, J., Wang, Y., & Yu, Y. (2023). Silencing CircEIF3I/miR-526b-5p Axis Epigenetically Targets HGF/c-Met Signal to Hinder the Malignant Growth, Metastasis and Angiogenesis of Hepatocellular Carcinoma. Biochemical Genetics, 61(1), 48-68.

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   224. Liu, P., Zhou, J., Xu, J., Ruan, G., Ding, C., & Wang, K. Vitamin D Plays a Protective Role in Osteoarthritis by Inhibiting the Nuclear Transcription Factor-κB (NF-κB)-Regulated Adenosine Monophosphate Activated Protein Kinase (AMPK)/Mammalian Target of Rapamycin (mTOR) Signaling Pathway to Activate Chondrocyte Autophagy.

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   227. Wang, B. et al. (2023). Oxidative stress initiates RIPK3/MLKL-mediated corneal epithelial necroptosis and NLRP3 inflammasome signaling during fungal keratitis. The American Journal of Pathology. 
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   231. Buerer, L., Clark, N., Welch, A., Duan, C., Taggart, A., Townley, B., ... & Fairbrother, W. (2023). The debranching enzyme Dbr1 regulates lariat turnover and intron splicing.

   232. Wang, S., Cai, Q., Xu, L., Sun, Y., Wang, M., Wang, Y., ... & Ni, Z. (2023). Isoalantolactone relieves depression-like behaviors in mice after chronic social defeat stress via the gut-brain axis. Psychopharmacology, 1-13.

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   234. Clark, N. E., Katolik, A., Gallant, P., Welch, A., Murphy, E., Buerer, L., ... & Fairbrother, W. G. (2023). Activation of human RNA lariat debranching enzyme Dbr1 by binding protein TTDN1 occurs though an intrinsically disordered C-terminal domain. Journal of Biological Chemistry, 105100.

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   236. Li, S., Wang, L., Wang, J., Liang, B., Gao, W., Huang, Y., ... & Wang, Z. (2023). Inhibition of AGEs-RAGE-PP2A axis alleviates cognitive impairment after chronic heart failure. Cellular and Molecular Biology, 69(5), 179-185.

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   239. Hou, J., Yun, Y., Jeon, B., Baek, J., & Kim, S. (2023). Ginsenoside F1-Mediated Telomere Preservation Delays Cellular Senescence. International Journal of Molecular Sciences, 24(18), 14241.

   240. Chu, C., Wang, X., Chen, F., Yang, C., Shi, L., Xu, W., ... & Ding, W. (2023). Neutrophil extracellular traps aggravate intestinal epithelial necroptosis in ischaemia–reperfusion by regulating TLR4/RIPK3/FUNDC1‐required mitophagy. Cell Proliferation, e13538.

   241. Szabó, Á., Spekker, E., Szűcs, M., Takeda, K., Ozaki, K., Inoue, H., ... & Tanaka, M. (2023). Exploring the Neurobiological Roots of Emotional Behavior in Tryptophan Metabolism: Insights from Novel Kynurenine Aminotransferase Knockout Mice.

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   244. Maeda, S., Segawa, K., Konishi, H., Iwamoto, K., & Nakamura, N. (2023). Development of scaffold-free tissue-engineered constructs with serum-free media from mesenchymal stem cell-derived cells for cartilage repair and long-term preservation.

   245. Yang, F., Jing, X., Dong, R., Zhou, L., Xu, X., Dong, Y., ... & He, W. (2023). Glucose Oxidase of a Crucifer-Specialized Insect: A Potential Role in Suppressing Plant Defense via Modulating Antagonistic Plant Hormones. Journal of Agricultural and Food Chemistry.

   246. Nie, D. Y., Tabor, J. R., Li, J., Kutera, M., St-Germain, J., Hanley, R. P., ... & Arrowsmith, C. (2023). Recruitment of FBXO22 for Targeted Degradation of NSD2. bioRxiv, 2023-11.

   247. Huang, M., Zheng, X., Zhang, Y., Wang, R., & Wei, X. (2023). Comparative proteomics analysis of kidney in chicken infected by infectious bronchitis virus. Poultry Science, 103259.

   248. Shin, H., & Vandergon, T. (2023). Polystyrene Nanoplastics Initiate the HPA Axis in Hypothalamic Nerve Cells.

   249. Nagatomo, A., Kohno, M., Kawakami, H., Manse, Y., & Morikawa, T. (2023). Inhibitory effect of trans-tiliroside on very low-density lipoprotein secretion in HepG2 cells and mouse liver. Journal of Natural Medicines, 1-11.

   250. Li, Y., Yang, X., Han, J., Bai, B., Li, Y., Shang, C., ... & Zhu, Y. (2023). Peimisine ameliorates DSS-induced colitis by suppressing Jak–Stat activation and alleviating gut microbiota dysbiosis in mice. Journal of Pharmacy and Pharmacology, rgad091.

   251. Wen, X., Fang, G., Li, H., Jiang, Z., Du, X., Liao, Z., ... & Zhang, Z. (2023). CircIRAK3 exerts negative feedback regulation on inflammation by binding to HNRNP U and destabilizing proinflammatory cytokine mRNA in osteoarthritis and chondrogenesis. International Journal of Biological Macromolecules, 128453.

   252. Maeda, S., Matsumoto, M., Segawa, K., & Iwamoto, K. (2023). Development of scaffold-free tissue-engineered constructs derived from mesenchymal stem cells with serum-free media for cartilage repair and long-term preservation.

   253. Szabó, Á., Spekker, E., Szűcs, M., Takeda, K., Ozaki, K., Inoue, H., ... & Tanaka, M. (2023). Unraveling the Neurobiological Roots of Despair: Insights from Novel Kynurenine Aminotransferase II Knockout Mice.

   254. Cao, Y., Chen, X., Pan, F., Wang, M., Zhuang, H., Chen, J., ... & Wang, T. (2023). Xinmaikang-mediated mitophagy attenuates atherosclerosis via the PINK1/Parkin signaling pathway. Phytomedicine, 119, 154955.

   255. Wang B, Yang X, Zuo X, Zeng H, Wang X, Huang H, He D, Wang L, Ouyang H, Yuan J. Oxidative Stress Initiates Receptor-Interacting Protein Kinase-3/Mixed Lineage Kinase Domain-Like-Mediated Corneal Epithelial Necroptosis and Nucleotide-Binding Oligomerization Domain-Like Receptor Protein 3 Inflammasome Signaling during Fungal Keratitis. Am J Pathol. 2023 Jul;193(7):883-898. doi: 10.1016/j.ajpath.2023.04.004. Epub 2023 May 4. PMID: 37146965.

   256. Li, H., Cheng, S., Huo, J., Dong, K., Ding, Y., Man, C., ... & Jiang, Y. (2023). Lactobacillus plantarum J26 Alleviating Alcohol-Induced Liver Inflammation by Maintaining the Intestinal Barrier and Regulating MAPK Signaling Pathways. Nutrients, 15(1), 190.

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   261. Rozpędek-Kamińska, W., Galita, G., Saramowicz, K., Granek, Z., Barczuk, J., Siwecka, N., ... & Majsterek, I. (2024). Evaluation of the LDN-0060609 PERK Inhibitor as a Selective Treatment for Primary Open-Angle Glaucoma: An In Vitro Study on Human Retinal Astrocytes. International Journal of Molecular Sciences, 25(2), 728.

   262. Chu, P. Y., Hsu, C. L., Lin, Y. A., Pan, Y. C., Dai, Y. H., Yu, Y. C., ... & Wu, Y. C. (2024). Effects of Citrus depressa Hayata juice on high-fat diet-induced obesity in HBV transgenic mice. Heliyon.

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   267. Zhang, J., Qin, M., Kao, C., Shi, Y., Yang, Z., Chen, T., ... & Ding, L. (2024). PDCD4 deficiency improved 4-vinylcyclohexene dioxide-induced mouse premature ovarian insufficiency. Reproductive BioMedicine Online, 48(4), 103685.

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   269. Chen, L., Adang, M. J., & Shen, G. A Novel Spider Venom Peptide from the Predatory Mite Neoseiulus Barkeri Shows Lethal Effect on Phytophagous Pests. Available at SSRN 4719195.

   270. Cao, C., Yu, P., Chu, C., Wang, Z., Xu, W., Cheng, F., ... & Qiu, Z. (2024). Magnesium hydride attenuates intestinal barrier injury during hemorrhage shock by regulating neutrophil extracellular trap formation via the ROS/MAPK/PAD4 pathway. International Immunopharmacology, 130, 111688.

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   273. Zhang, J., Qin, M., Kao, C., Shi, Y., Yang, Z., Chen, T., ... & Ding, L. (2024). PDCD4 deficiency improved 4-vinylcyclohexene dioxide-induced mouse premature ovarian insufficiency. Reproductive BioMedicine Online, 48(4), 103685.

   274. Chen, X., Cao, Y., Guo, Y., Liu, J., Ye, X., Li, H., ... & Wang, T. (2024). microRNA-125b-1-3p mediates autophagy via the RRAGD/mTOR/ULK1 signaling pathway and mitigates atherosclerosis progression. Cellular Signalling, 111136.

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   276. Le, T. Q., Meesiripan, N., Sanggrajang, S., Suwanpidokkul, N., Prayakprom, P., Bodhibukkana, C., ... & Rattanapinyopituk, K. (2024). Anti-proliferative and apoptotic effect of cannabinoids on human pancreatic ductal adenocarcinoma xenograft in BALB/c nude mice model. Scientific Reports, 14(1), 6515.

   277. Xie, L., Cao, Y., Ren, R., Yang, J., Xue, F., Sui, W., & Zhang, Y. (2024). Combination of ADAM17 knockdown with eplerenone is more effective than single therapy in ameliorating diabetic cardiomyopathy. Frontiers in Pharmacology, 15, 1364827.

   278. Fu, D., Gao, S., Li, J. N., Cui, Y. H., Luo, Y. W., Zhong, Y. J., ... & Hu, Z. L. (2024). P75NTR+ CD64+ neutrophils promote sepsis-induced acute lung injury. Clinical Immunology, 110206.

   279. Qi, X., Yu, X., Wei, L., Jiang, H., Dong, J., Li, H., ... & Li, T. (2024). Novel α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole‐propionic acid receptor (AMPAR) potentiator LT‐102: A promising therapeutic agent for treating cognitive impairment associated with schizophrenia. CNS Neuroscience & Therapeutics, 30(4).

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   281. Deng, X., Ren, J., Chen, K., Zhang, J., Zhang, Q., Zeng, J., ... & Zhu, J. (2024). Mas receptor activation facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice. Journal of Neuroinflammation, 21(1), 1-21.

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